![]() This intuition reflects a well-known “guilt-by-association” principle that genes (or, more precisely, their products) forming an interaction network are more likely to have similar functions and co-expression patterns. Networks formed by interactions among phenotype-associated genes, or, more precisely, their protein products, are thought to have high connectivity. Network properties, such as connectivity (aka degree distribution), can be compared to better understand the relationships among phenotypes. Consequently, methods to quantitatively assess these phenotype-associated networks of functionally-related genes have been developed. #COHERENCE X FULL#Such interaction modules may be viewed as connected subnetworks within the full interactome and may contain all the molecular determinants of a certain phenotype. This observation has been verified systematically for a large number of diseases, thus confirming a fundamental hypothesis of the interactome-based approach to understanding human phenotypes, namely that disease- and trait-associated genes tend to form interaction modules. Many studies have shown that genetically-driven phenotypes are often associated with functionally related genes that are more likely to form networks of interacting protein products. These limitations of current generation GWAS might stem from the yet incomplete knowledge of genetic determinants of complex phenotypes, the potential heterogeneity and/or the causes other than genetics. Furthermore, the corresponding genes are often spread across different chromosomes with no known connection to one another, hindering understanding of the molecular mechanisms. However, GWAS findings explain only a fraction of heritability. Genome-wide association studies (GWAS) have significantly advanced our understanding of complex phenotypes by identifying disease- and trait-associated genetic markers and suggesting corresponding genes. Our results highlight gaps in our current knowledge of genetics and molecular mechanisms of complex phenotypes and suggest priorities for future GWASs. We present a general-purpose method for estimating and comparing the coherence of molecular-interaction gene networks that accounts for the network size and shape differences. We demonstrate that coherence and modularity measures capture distinct network properties. Metabolic traits and diseases were the most coherent, while psychiatric disorders and intelligence-related traits were the least coherent. We observed a range of coherence estimates for each category of phenotypes. Using STRING and BioGrid PPI databases, we compared the coherence of 116 phenotype-associated gene sets from GWAScatalog against size-matched KEGG pathways (the reference for high coherence) and random networks (the lower limit of coherence). We present a novel method for normalizing the coherence estimates, making them directly comparable. The internal degree distribution is defined by interaction counts within a phenotype-specific gene network, while the external degree distribution counts interactions with other genes in the whole protein–protein interaction (PPI) network. We introduce a metric for measuring coherence of molecular-interaction networks as a slope of internal versus external distributions of the degree of interactions. However, direct comparison of the degree of interactions is difficult due to different sizes and configurations of phenotype-associated gene networks. Comparing the degree of interactions may help to better understand the coherence of phenotype-specific molecular mechanisms and the potential for therapeutic intervention. High/low degree of interactions is suggestive of coherent/random molecular mechanisms, respectively. Phenotypes such as height and intelligence, are thought to be a product of the collective effects of multiple phenotype-associated genes and interactions among their protein products. ![]()
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![]() It doesn’t sound like much, but if you’re scanning around an image to make sure your edits have been effectively and subtly applied, it’s a nightmare. Zoom into an image and pan around, and Luminar takes a second to render your new view properly, showing you a pixellated preview for nearly two seconds in the interim. We also liked the ability to perform an edit on one image, and then synchronize the changes to other images in your catalogue. The inclusion of a before-and-after slider is appreciated, as it lets you keep a bit of perspective over exactly what’s happening to your image. Still, there are some solid fundamental tools. Some edits tend towards the dramatic – use the slider at the bottom to reduce their intensity. Luminar al skin#More contentious-sounding tools, such as the skin blemish remover, are actually applied subtly, allowing Luminar to largely deliver on its claim of top-quality images in next to no time. Luminar AI does a nice job of detecting facial features and boosting them (whiter eyes and teeth, for instance), without damaging the rest of your image. We enjoyed similarly good results editing portraits. It works well, the results are good, and if you click the small ellipses icon just over the effect slider you’re launched into Luminar’s Edit panel, where you can adjust the nuts and bolts of your chosen effect. Choose your effect (they’re given unhelpfully non-descriptive names such as “Clean light” and“Forest Stream”), and then tailor how strongly its applied with a slider beneath. Luminar al professional#Using the suggested templates, we ended up with results which, much to this photographer’s chagrin, were pretty close to the professional results arrived at via protracted Photoshop sessions. We tried Luminar with a set of unedited raw images and were pleased with the results. Landscape edits are quickly and effectively applied. Luminar al series#In Templates, Luminar suggests what kind of image you have, and then gives you a series of recipes that spice it up, ranging from simple saturation-and-sharpening boosts to Instagram-friendly low-contrast filters. The way Luminar edits is broken down into Templates – which are one-click wonders that instantly spice up your photography – and Edits, where effects are automatically applied with your hand on the tiller, feathering in the changes Luminar thinks are best. Hopefully that's a bug that will be ironed out with a firmware fix. You don’t open images one at a time instead you add them to a catalog a slightly flawed process because our version of Luminar (1.0.1) had a propensity for forgetting where images were, flagging them with a not-found warning icon and forcing us to re-import the original shot, losing any edits we’ve made. The main UI owes a passing nod to Lightroom, at least structurally. Skylum Luminar AI at Amazon for $49 (opens in new tab).Luminar AI let you add entire skies as well. ![]() ![]() Swurve is expected to carry BIFMA level® 2 and SCS Global Services certification for Indoor Air Quality at the Indoor Advantage™ Gold level. Swurve, Keilhauer’s first Carbon Neutral chair, is built from the highest quality materials, is designed, and manufactured to last for many years, and is supported by Keilhauer’s standard 10-year warranty. Verified by third parties, every Swurve sold will produce net-zero carbon emissions. Where carbon emissions remain, such as during transportation, Keilhauer is investing in carbon reduction and climate change mitigation projects to offset. Keilhauer took every possible step to reduce carbon emissions: from sustainably sourcing materials, and responsible manufacturing, to a carefully thought-through end-of-life and recyclability plan. An elegant solution for meeting spaces of all sizes, it brings an organic feeling into the room with distinctive, sculptural design details.Īs Keilhauer’s first Carbon Neutral product, Swurve has been a project of passion for the company’s sustainability team. With that in mind, Keilhauer has introduced its Swurve seating collection, their first Carbon Neutral chair.ĭesigned by Andrew Jones for Keilhauer, the new conference chair features flowing lines and contained proportions. The furniture industry has worked diligently to utilize new technologies to improve the sustainability features of their new product introductions. Keilhauer’s first Carbon Neutral product, Swurve™ has been a project of passion for the company’s sustainability team. ![]() ![]() #Paladin quickbuild how toRUSSIAN: Limited Color Palette with Sam - Dirt and Grime with Liam - Painting Grayscale with Babs Tarr - Painting Fades with Marisha RayĪre you a Multilingual Critter, who likes to type, likes a little brain-teaser and have a few hours to spare? You can join the team by translating a slot in your favourite language.įor more information, read our How to Help Page, send us an Ask via Tumblr, or a tweet at be sure to join our Discord and meet the rest of the wonderful Critical Role Translate team, and help make Critical Role global! critical role CRTranslate translation crt critters slight format change sorting by show first RUSSIAN: Travis Willingham - Laura Bailey RUSSIAN: Critical Role and the Club of Misfits RUSSIAN: UnDeadwood Part I - UnDeadwood Part II - UnDeadwood Part III - UnDeadwood Part IV POLISH: Druid (Quick Build) - Combat Actions - Bard (Quick Build) - Spellcasting Basics - Advantage & Disadvantage - Sorcerer (Quick Build) - Leveling Up JAPANESE: Dice 101 - Rogue (Quick Build) - Ability Checks, Proficiencies & Saving Throws RUSSIAN: Mighty Nein Intro - C2E12 - C2E13 - C2E14 - C1E1 - C2E15 - C2E16 - Liam’s QuestĬZECH: What is Handbooker Helper? - Ability Scores - Ranger (Quick Build) - Death Saving Throws - Barbarian (Quick Build) - Ability Checks, Proficiencies & Saving Throws - Cleric (Quick Build) - Fighter (Quick Build) - Armor 101ĭUTCH: Condition Effects - Dragonborn (Quick Build) - Skills - Multiclassing - Gnome (Quick Build) - Feats - Half-Elf (Quick Build) - Backgrounds - Half-Orc (Quick Build) - Dwarf (Quick Build) PORTUGUESE (BRAZIL): Mighty Nein Intro - C2E8 GERMAN: Mighty Nein Intro - C1E2 - C2E15 - C2E16 Without further ado, we present the work of the past seven months:ĬHINESE (SIMPLIFIED & TRADITIONAL): C1E4 - C1E5 - C2E5ĭUTCH: C2E7 - C2E8 - C2E9 - C2E10 - C2E11 - C1E0 - C2E12 - C2E13 That being said, we did translate a whole bunch of episodes for you all. #Paladin quickbuild movieOur community has grown from a volunteer work project into a place where we play rpgs, read our translations to each other in our native languages aloud, have movie nights in various languages, read our favorite stories to each other, draw together and much, much more. Fortunately for us and those who appreciate our translations though, our actual ability to work on this project together online has been pretty much unchanged! We have done more than work hard, though - we have been playing hard too.Īs our hopes of meeting up in person this year dwindled, the community spirit actually lifted and we have come together in creative and previously untried ways. Just as about everyone else on this planet, our team has been impacted by Covid-19 in some ways. ![]() ![]() Mit weiterem Spielfortschritt schaltest du immer neue Zutaten, Gerichte und mehr frei. Unter anderem führt dich dein Weg in folgende Etablissements: Fast-Food-Restaurant. Don't worry, you can use another of our generators that we recommend in that situation, or try again in a few minutes at . Im Kochspiel Cooking Fever spielst du dich durch mehrere Läden. Stay songs and utilize Cooking Fever cheat codes and also win on the game. 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No need to wait for the next stable release to benefit from bug-fixes!īesides Code::Blocks itself, you can compile extra plugins from contributors to extend its functionality. It gives you that much more flexibility though because you get access to any bug-fixing we do at the time we do it. This option is the most flexible of all but requires a little bit more work to setup. DOWNLOAD LATEST VERSION OF ECLIPSE IDE FOR MAC UPDATEDownloading the source code and building it yourself puts you in great control and also makes it easier for you to update to newer versions or, even better, create patches for bugs you may find and contributing them back to the community so everyone benefits. Download the latest MyEclipse: Version 2022.1.0a MyEclipse. If you feel comfortable building applications from source, then this is the recommend way to download Code::Blocks. Download MyEclipse and get the best Java EE IDE for the enterprise. If you want to provide some, make sure to announce in the forums such that we can put it on the official C::B homepage. Other distributions usually follow provided by the community (big “Thank you!” for that!). Please note that we consider nightly builds to be stable, usually, unless stated otherwise. There are also more recent so-called nightly builds available in the forums. DOWNLOAD LATEST VERSION OF ECLIPSE IDE FOR MAC HOW TODownload the setup file, run it on your computer and Code::Blocks will be installed, ready for you to work with it. Eclipse latest version download for windows 7 64 bit how to Eclipse latest version download for windows 7 64 bit mac osx If you receive a security warning, click Run. It contains what you need to build applications based on Eclipse technology, including integrated development environments IDE, and rich client applications using the Eclipse Rich Client. This is the easy way for installing Code::Blocks. Eclipse Classic is the most recent release from the Eclipse top-level project. DOWNLOAD LATEST VERSION OF ECLIPSE IDE FOR MAC INSTALLBy restarting your computer it refreshes system memory and allows changes made by installers and uninstallers to take effect.There are different ways to download and install Code::Blocks on your computer:
![]() This is all pretty standard, but then Neon Abyss adds spice - crystals are collected for unlocking nodes and some shop doors, and they also add to the Wisdom meter whenever they’re used. Gold is used for buying stuff from the store, bombs blow up walls, stone chests and revealing hidden rooms, and keys are for opening locked doors and treasure chests. Each map is procedural, and after 5 to 7 maps, a run ends with a God-themed boss.Īlong the way to a boss fight, the player will collect gold, bombs, keys, crystals, items (passive buffs) and eggs that hatch into pets that help (or hinder). Neon Abyss is a 2D platformer/exploration game with rooms split up in metroidvania fashion offering shops, combat encounters, platforming sections, and more. The plot seems to be that the player is tasked by Greek goddess Athena with killing other gods while set against an evocative 16-bit neon theme, but I am not entirely clear on this, and I’m not sure it matters. With pan-global genre credentials established, it is now Chinese developer Veewo Games’ turn to put their spin on roguelikes with Neon Abyss. There are other luminaries in the genre such as Spelunky and Faster Than Light, but I can already see my editor massaging his brow and sighing ‘ AJ, please just get on with the review and stop this rambling intro to roguelikes, and no you can’t call them “Mystery Dungeons” for the rest of the review’. Although the forerunner and namesake are from the US, during the dark days when that style fell out of fashion, it was Japanese developer Chunsoft tirelessly iterating on Shiren the Wanderer that kept the ‘Mystery Dungeon’ genre alive. The roguelike genre has become a go-to in the indie scene, and one that’s been met with acceptance. WTF Nothing for something is too often an outcome. LOW The game has more content than playtime. HIGH Blasting through gods like they’re nothing. ![]() ![]() If you’d like your aggregate delivered then simply place an order / quote request and we will take care of the rest! We also invite you to come and visit our Andover aggregate yard. You may learn more about the different aggregate usage here. You can feel comfortable that you will get the highest quality aggregate material for just about any landscaping or hardscaping project. We will do everything we can to deliver your stone product on or before your delivery date (we will contact you as soon as we have delivery dates available for you). We strive to provide our customers with the best crushed stone at the lowest prices. This depends on how many orders are ahead of you, weather conditions, traffic/accidents and so forth. Anyone needing material for the morning of should get delivery day before to assure product is on site for time needed to be used. 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Solo play is fun and the game is balanced appropriately for solo play. Like previous games, Borderlands 3 can be played solo and co-op. The second game built upon the first game’s gameplay so well that many expected, myself included, how Gearbox would expand and improve on Borderlands 2. Gameplayīorderlands has always had a solid gameplay foundation. It’s a shame, because Gearbox can do a great villain but it feels like a step back in that department. The twins try way too hard to be evil and edgy and most of their jokes and one liners fall flat. The Calypso Twins had potential to be great villains but they would never be able to capture the sheer excellent twattery of Handsome Jack. The story’s biggest weakness are the main villains. There are moments where Borderlands 3 tries too hard to make you laugh, with the end result being a low groan. The funny moments aren’t as funny as the previous game. It starts off well but around the half way point you can tell that the story isn’t going to be fulfilling as the second game. The story for Borderlands 3 isn’t bad but it isn’t as cleverly written or as good as Borderlands 2. #BORDERLANDS 2 SEASON PASS ALL DLC FULL#Now I’m not going to give full 1000-1500+ word reviews for each part of Borderlands 3, otherwise this review incredibly long and you’ll go grey reading it.Įnough of me rambling on like a numskull, here’s the review. I’m reviewing Borderlands 3 and all of its major DLCs in one article. Why not repackage what I have already done and turn it into something different.Īll of the “major” DLC is now out for Borderlands 3 and so I decided to a big bundle review. The Borderlands 3 review has sat unfinished in my drafts for a while now and I was thinking of just deleting it. I was originally going to review Borderlands 3 after I completed it but unfortunately, I never got around to it. This review is going to be a bit different to the others that I have done on this site. ![]() ![]() On the origins of the animated film, especially in the United States, see Donald Crafton’s fascinating Before Mickey: The Animated Film, 1898–1928 (MIT Press, 1982).Īdditional examples of early animation may be viewed online at the Library of Congress’s exhibition Origins of American Animation, based on The Library of Congress Video Collection, Volume 3: Origins of American Animation, 1900–1921. The new prints are available at the Museum of Modern Art and the NFSA. Preservationists, however, were able to replace a number of decayed frames in the intertitles by “stretch printing” the adjacent frames. dated slang A method of police interrogation in which one of two interrogators behaves in an overtly aggressive and. Nitrate “blooms” are visible in several scenes, particularly in the initial live-action shots with Bud Fisher. #MUTT AND JEFF ARCHIVE#The single known print of On Strike was found at the National Film and Sound Archive of Australia, which generously lent the nitrate source material to make the preservation copies. Click on their names to read their papers.) (Thanks to Erin Hanna and Nancy McVittie, graduate students of Richard Abel at the University of Michigan, for their invaluable research on this cartoon. #MUTT AND JEFF MOVIE#“About 3000” cells later, Mutt and Jeff’s production bombs with the movie audience and the actors return to their “boss” as grateful employees. What follows is a fascinating demonstration of the time-intensive animation process then in use. With the battle cry of “Arbitrate me eye!!!” they decide to strike and make cartoons on their own. When Mutt (the tall one, his diminutive name notwithstanding) and Jeff see how lavishly the celebrated Fisher lives off their labors, the duo demand a bigger cut. On Strike offers an alternative version from the producer’s point of view. History Created by American cartoonist Bud Fischer, Mutt and Jeff was one of the first popular newspaper strips and the first that was published daily, debuting in the San Francisco Chronicle in 1907 before moving to the San Francisco Examiner in 1908. This film episode continues the tradition by working into the storyline parallels to the 1919 Actors Equity Association strike, which spread to eight cities before the actors won a settlement. Mutt and Jeff is a comic strip referenced in the first season of Boardwalk Empire. Launched in San Francisco in 1907, the original Mutt and Jeff strip often commented on politics. A shrewd entrepreneur, he kept the copyright and remained in the spotlight after he expanded his characters into film and farmed out the animation work to the studio of Raoul Barré and Charles Bowers. Although not the first daily newspaper comic strip to use an ongoing narrative, Mutt and Jeff was by far the most successful and made Fisher a small fortune from syndication and merchandising. On Strike is one of more than 300 animated ‘half-reelers’ produced between 19 starring the popular American comic-strip characters Mutt and Jeff-and is unusual in featuring live-action shots of its creator, Bud Fisher. Running Time: 7 minutes (silent, no music). Transfer Note: Digital file made from a 35mm negative. It originated with that meaning in the UK in the 1960s and is sometimes shortened just to mutton. Fisher became a wealthy celebrity as the world's highest paid cartoonist during the 1920s and lived the high life, buying Rolls-Royces and racehorses, eventually moving to an apartment on New York's Park Avenue.įollowing Fisher's death in 1954, Al Smith, Fisher's longtime assistant, continued the strip into the 1980s.Production Company: Bud Fisher Films Corporation, distributed by the Fox Film Corporation. The Mutt n Jeff variant is is a nice example of Cockney rhyming slang. "Mutt and Jeff" became a national hit in syndication and is recognized as the first successful daily comic strip, spinning off into comic books, animated shorts and merchandise. In 1915 Fisher made it official by changing the name of the strip to "Mutt and Jeff." The next year, Mutt met the scheming Jeff in an insane asylum, and a partnership was born. Mutt," the story of inept horserace gambler Augustus Mutt, in 1907. In his first year of study at the University of Chicago, he left school to take a job at the San Francisco Chronicle, where he drew cartoons and did page layouts for the sports department. Harry Conway "Bud" Fisher was born in Chicago in 1884. ![]() |
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